Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetaminophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | MEN1 | O00255 | 3/20 | 0.83 |
| ▸ | CA12 | O43570 | 1/20 | 0.83 |
| ▸ | BRD4 | O60885 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | CA1 | P00915 | 1/20 | 0.83 |
| ▸ | CA2 | P00918 | 1/20 | 0.83 |
| ▸ | MB | P02144 | 1/20 | 0.83 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.83 |
| ▸ | CA3 | P07451 | 1/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | RARG | P13631 | 1/20 | 0.83 |
| ▸ | TSHR | P16473 | 1/20 | 0.83 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.83 |
| ▸ | CA4 | P22748 | 1/20 | 0.83 |
| ▸ | CA7 | P43166 | 1/20 | 0.83 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.83 |
| ▸ | CA9 | Q16790 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetaminophen SCHEMBL11284717 | 0.96 | MAPT (0.83) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL27999125 | 0.96 | MAPT (0.91) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetanilide SCHEMBL28153387 | 0.94 | NAPRT (0.83) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL28267915 | 0.94 | KMT2A (0.95) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL28994743 | 0.91 | KMT2A (0.91) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL9786571 | 0.91 | KMT2A (0.91) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL3480 | 0.91 | KMT2A (1.00) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL8937727 | 0.91 | KMT2A (1.00) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL252939 | 0.91 | KMT2A (1.00) | MAPTKMT2AALDH1A1MEN1CA12 | |
| Acetaminophen SCHEMBL28852823 | 0.90 | MAPT (0.74) | MAPTKMT2AALDH1A1MEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105982853-A | Paracetamol infusion solution and preparation method and application thereof | 成都医学院 | 2016-10-05 | — | — | CN | disclosed |