SCHEMBL28083308

SCHEMBL28083308

COC(=O)c1cncc(CN=[N+]=[N-])c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.50
CYP2A6 P11509 1/20 0.40
ALDH1A1 P00352 2/20 0.40
CYP11B1 P15538 2/20 0.39
CYP11B2 P19099 2/20 0.39
HDAC8 Q9BY41 4/20 0.38
HDAC1 Q13547 2/20 0.38
HDAC2 Q92769 2/20 0.38
HDAC3 O15379 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
LOXL2 Q9Y4K0 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
SMYD3 Q9H7B4 1/20 0.35
GRM5 P41594 1/20 0.35
KDM4E B2RXH2 1/20 0.35
S1PR1 P21453 1/20 0.34
KDR P35968 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16147434 0.83 CA12 (0.43) ALDH1A1HDAC8HDAC1HDAC2HDAC3
SCHEMBL13555494 0.78 LOXL2 (0.59) ALDH1A1LOXL2CYP4F2CYP4A11KDM4E
SCHEMBL16405265 0.78 SLC7A5 (0.51) ATMALDH1A1HDAC8HDAC1HDAC2
SCHEMBL845224 0.78 ATM (0.62) ATMCYP2A6ALDH1A1CYP11B1CYP11B2
SCHEMBL13591062 0.77 HDAC3 (0.55) ALDH1A1HDAC8HDAC1HDAC2HDAC3
SCHEMBL13464985 0.77 HDAC8 (0.38) ALDH1A1HDAC8HDAC1HDAC2HDAC3
SCHEMBL21711984 0.77 NOTUM (0.46) ALDH1A1HDAC8HDAC1HDAC2HDAC3
SCHEMBL15424210 0.77 ALDH1A1 (0.40) ALDH1A1HDAC8HDAC1HDAC2HDAC3
SCHEMBL2008389 0.77 ATM (0.66) ATMCYP2A6ALDH1A1CYP11B1CYP11B2
SCHEMBL6978122 0.77 ATM (0.61) ATMCYP2A6ALDH1A1CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103502218-B Compounds and methods for for conjugating biomolecules 生命科技公司 2016-08-17 CN disclosed