Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | HTR5A | P47898 | 3/20 | 0.36 |
| ▸ | OGA | O60502 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810531 | 0.93 | MRGPRX1 (0.48) | MRGPRX1ESR1ESR2OGACETP | |
| SCHEMBL2813871 | 0.92 | MRGPRX1 (0.39) | MRGPRX1ESR1ESR2OGACETP | |
| SCHEMBL2816668 | 0.92 | MRGPRX1 (0.39) | MRGPRX1ESR1ESR2HRH4HRH1 | |
| SCHEMBL2812302 | 0.91 | ACHE (0.37) | HRH4HRH1HTR5ACYP2D6HRH2 | |
| SCHEMBL2810273 | 0.89 | ADORA3 (0.41) | MRGPRX1OGAADORA3ADORA2AADORA1 | |
| SCHEMBL2813941 | 0.89 | ADORA3 (0.41) | MRGPRX1OGAADORA3ADORA2AADORA1 | |
| SCHEMBL2816649 | 0.88 | MRGPRX1 (0.38) | MRGPRX1ESR1ESR2CETPSIGMAR1 | |
| SCHEMBL2814269 | 0.88 | RXFP1 (0.36) | MRGPRX1ESR1ESR2CETPSIGMAR1 | |
| SCHEMBL2812918 | 0.87 | MRGPRX1 (0.38) | MRGPRX1CETPHTR2BHTR6SIGMAR1 | |
| SCHEMBL2812211 | 0.87 | OGA (0.43) | MRGPRX1OGAROCK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | MRGPRX1 2755/4885ESR1 3470/4885ESR2 3400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.