SCHEMBL28084403

SCHEMBL28084403

O=C(Nc1cccc(Cl)c1)c1ccccc1I

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FADS1 O60427 3/20 0.70
MEN1 O00255 3/20 0.68
KMT2A Q03164 3/20 0.68
TDP1 Q9NUW8 1/20 0.68
NPC1 O15118 2/20 0.62
RAB9A P51151 2/20 0.62
P2RX1 P51575 1/20 0.61
P2RX4 Q99571 1/20 0.61
P2RX7 Q99572 1/20 0.61
GRM5 P41594 3/20 0.60
RXFP1 Q9HBX9 1/20 0.58
GRM4 Q14833 1/20 0.57
HDAC6 Q9UBN7 1/20 0.57
LMNA P02545 2/20 0.57
MAPT P10636 2/20 0.57
HTT P42858 2/20 0.57
ALDH1A1 P00352 1/20 0.57
MAOB P27338 2/20 0.56
KCNK3 O14649 1/20 0.55
KCNK9 Q9NPC2 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15778718 0.84 FADS1 (0.74) FADS1MEN1KMT2ATDP1NPC1
SCHEMBL11588351 0.83 MEN1 (0.70) FADS1MEN1KMT2ATDP1NPC1
SCHEMBL30573259 0.83 MEN1 (0.70) FADS1MEN1KMT2ATDP1NPC1
SCHEMBL2701738 0.83 FADS1 (1.00) FADS1MEN1KMT2ANPC1RAB9A
SCHEMBL28496487 0.82 MEN1 (0.74) MEN1KMT2ATDP1NPC1P2RX1
Benodanil SCHEMBL18736 0.81 MEN1 (1.00) MEN1KMT2ATDP1NPC1RAB9A
Benodanil SCHEMBL29402073 0.81 MEN1 (1.00) MEN1KMT2ATDP1NPC1RAB9A
SCHEMBL472983 0.81 FADS1 (0.78) FADS1MEN1KMT2ANPC1RAB9A
SCHEMBL2308674 0.81 FADS1 (0.70) FADS1MEN1KMT2ANPC1RAB9A
SCHEMBL12225785 0.81 FADS1 (0.70) FADS1MEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117466799-B N-substituted phthalic acid diamide preparation method of imine compound 西北师范大学 2024-12-24 CN claimed
CN-117466799-A Preparation method of N-substituted phthalimide compound 西北师范大学 2024-01-30 CN claimed
CN-117466799-B N-substituted phthalic acid diamide preparation method of imine compound 西北师范大学 2024-12-24 CN disclosed
CN-117466799-A Preparation method of N-substituted phthalimide compound 西北师范大学 2024-01-30 CN disclosed
CN-104163799-B 3-amino-4-Cyanoisoquinoline-1(2H) preparation method of-one derivant 苏州大学 2016-08-17 CN disclosed