Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30441012 | 0.83 | KDM4E (0.46) | L3MBTL1METAP1ALDH1A1LMNAPOLB | |
| SCHEMBL5376069 | 0.83 | TLR7 (0.45) | L3MBTL1METAP1ALDH1A1LMNAPOLB | |
| SCHEMBL21358025 | 0.81 | GABRA1 (0.42) | L3MBTL1METAP1ALDH1A1LMNAPOLB | |
| SCHEMBL30322596 | 0.81 | L3MBTL1 (0.41) | L3MBTL1METAP1ALDH1A1LMNAPOLB | |
| SCHEMBL2414354 | 0.81 | POLB (0.44) | L3MBTL1METAP1ALDH1A1LMNAPOLB | |
| SCHEMBL27593401 | 0.81 | GRM4 (0.41) | L3MBTL1METAP1ALDH1A1LMNAPOLB | |
| Ammonia Solution, Strong SCHEMBL28013995 | 0.81 | KDM4E (0.44) | L3MBTL1METAP1ALDH1A1LMNAPOLB | |
| SCHEMBL31347575 | 0.80 | L3MBTL1 (0.62) | L3MBTL1BRD4ALDH1A1POLBCYP1A2 | |
| SCHEMBL128711 | 0.80 | L3MBTL1 (0.62) | L3MBTL1BRD4ALDH1A1POLBCYP1A2 | |
| SCHEMBL28851020 | 0.80 | L3MBTL1 (0.45) | L3MBTL1BRD4ALDH1A1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196803-A | 5-fluoropyrimidine heterocyclic compound with Wnt signal channel inhibition activity and application thereof | 苏州云轩医药科技有限公司 | 2020-05-26 | — | — | CN | disclosed |
| CN-106565673-B | 5-fluoropyrimidine heterocyclic compound with Wnt signal channel inhibition activity and application thereof | 苏州云轩医药科技有限公司 | 2019-12-06 | — | — | CN | disclosed |
| CN-106117193-A | New Hete rocyclic derivatives and the application in nervous system disease is treated thereof | 诺华股份有限公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-103403001-B | Heterocyclic derivatives and their use in the treatment of neurological disorders | 诺瓦提斯公司 | 2016-08-17 | — | — | CN | disclosed |