Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957028 | 0.83 | EGFR (0.50) | NPC1EGFRNR2F2HIF1AMEN1 | |
| SCHEMBL19641368 | 0.83 | NPC1 (0.51) | NPC1EGFRPOLBNR2F2CCNB2 | |
| SCHEMBL27787171 | 0.82 | KDM4E (0.51) | EGFRPOLBKMT2AMAPTHPGD | |
| SCHEMBL19641279 | 0.82 | NPC1 (0.50) | NPC1EGFRPOLBNR2F2CCNB2 | |
| SCHEMBL12675591 | 0.80 | NPC1 (0.64) | NPC1EGFRPOLBNR2F2HIF1A | |
| SCHEMBL28283742 | 0.80 | NPC1 (0.64) | NPC1EGFRPOLBNR2F2HIF1A | |
| SCHEMBL8835483 | 0.79 | RAB9A (0.60) | NPC1MEN1KMT2AMAPTLMNA | |
| SCHEMBL21382408 | 0.79 | NPC1 (0.62) | NPC1EGFRPOLBNR2F2HIF1A | |
| SCHEMBL6131117 | 0.79 | NPC1 (0.62) | NPC1EGFRPOLBNR2F2HIF1A | |
| SCHEMBL1347342 | 0.79 | NPC1 (0.62) | NPC1EGFRPOLBNR2F2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106220623-A | Compounds and methods for and indication thereof for kinases regulation | 普莱希科公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-102947305-B | Compounds and methods for kinase modulation and indications therefor | 普莱希科公司 | 2016-07-06 | — | — | CN | disclosed |