SCHEMBL28085635

SCHEMBL28085635

NC(=O)c1cc(F)c(F)c(F)c1F.NC(=O)c1cc(F)c(F)c(F)c1F

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.45
CES2 O00748 4/20 0.43
CES1 P23141 4/20 0.43
PARP1 P09874 3/20 0.39
ROCK2 O75116 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CA1 P00915 3/20 0.38
CA2 P00918 3/20 0.38
CA4 P22748 2/20 0.38
CRBN Q96SW2 1/20 0.37
MAP2K2 P36507 1/20 0.36
MAP2K1 Q02750 1/20 0.36
CTSL P07711 1/20 0.35
CA12 O43570 1/20 0.33
CA7 P43166 1/20 0.33
CA13 Q8N1Q1 1/20 0.33
CASP1 P29466 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL829400 1.00 DGAT1 (0.45) DGAT1CES2CES1PARP1ROCK2
SCHEMBL7813369 0.82 HSD17B1 (0.44) DGAT1CES2CES1
SCHEMBL4591061 0.82 DGAT1 (0.42) DGAT1CES2CES1PARP1ROCK2
SCHEMBL30995317 0.82 DGAT1 (0.42) DGAT1CES2CES1PARP1ROCK2
SCHEMBL9491069 0.82 DGAT1 (0.42) DGAT1CES2CES1PARP1ROCK2
SCHEMBL811079 0.82 DGAT1 (0.42) DGAT1CES2CES1PARP1ROCK2
Hydrochloric Acid SCHEMBL30995407 0.80 DGAT1 (0.41) DGAT1CES2CES1PARP1ROCK2
SCHEMBL25679030 0.80 DGAT1 (0.50) DGAT1CES2CES1PARP1ROCK2
SCHEMBL4514123 0.80 DGAT1 (0.41) DGAT1CES2CES1PARP1ROCK2
SCHEMBL8727078 0.80 DGAT1 (0.41) DGAT1CES2CES1PARP1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105732428-A Tetrafluorobenzonitrile production method 江苏维尤纳特精细化工有限公司 2016-07-06 CN disclosed