Sugi Predict

Sugi Predict / Compounds / Paramethasone

Paramethasone

Paramethasone

SCHEMBL28086288

C=C1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 5/20 0.56
▸ AR P10275 2/20 0.56
▸ NR3C1 P04150 8/20 0.55
▸ HSD17B10 Q99714 11/20 0.52
▸ HIF1A Q16665 7/20 0.52
▸ CYP3A4 P08684 5/20 0.52
▸ SERPINA6 P08185 3/20 0.52
▸ ABCB11 O95342 3/20 0.52
▸ CYP2C19 P33261 3/20 0.52
▸ NR3C2 P08235 2/20 0.52
▸ TNF P01375 1/20 0.52
▸ IL6 P05231 1/20 0.52
▸ GLUL P15104 1/20 0.52
▸ ADAM17 P78536 1/20 0.52
▸ GPBAR1 Q8TDU6 1/20 0.52
▸ ALDH1A1 P00352 3/20 0.51
▸ LMNA P02545 2/20 0.51
▸ SHBG P04278 2/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ CYP2D6 P10635 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Paramethasone SCHEMBL13723822 0.92 PGR (0.66) PGRARNR3C1HSD17B10HIF1A
Paramethasone SCHEMBL10532962 0.87 PGR (0.70) PGRARNR3C1HSD17B10HIF1A
Paramethasone SCHEMBL4471853 0.87 PGR (0.68) PGRARNR3C1HSD17B10HIF1A
Meprednisone SCHEMBL10532955 0.85 PGR (0.68) PGRARNR3C1HSD17B10HIF1A
Paramethasone SCHEMBL7078196 0.85 PGR (0.76) PGRARNR3C1HSD17B10HIF1A
Prednylidene SCHEMBL28089752 0.82 HSD17B10 (0.72) PGRARNR3C1HSD17B10HIF1A
Prednisolone SCHEMBL11710056 0.82 HSD17B10 (0.76) PGRARNR3C1HSD17B10HIF1A
Meprednisone SCHEMBL9746961 0.82 HSD17B10 (0.66) PGRARNR3C1HSD17B10HIF1A
Paramethasone SCHEMBL18130394 0.82 PGR (0.77) PGRARNR3C1HSD17B10HIF1A
Methylprednisolone SCHEMBL8902882 0.81 HSD17B10 (0.73) PGRARNR3C1HSD17B10HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103717597-B Heterocyclic compounds as kinase inhibitors 原真股份有限公司 2017-07-04 — — CN disclosed
CN-103492389-B Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases 原真股份有限公司 2016-09-14 — — CN disclosed