Paramethasone

SCHEMBL4471853

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nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Paramethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	8/20	0.66

▸	PGR	P06401	6/20	0.68

▸	AR	P10275	2/20	0.68

▸	HIF1A	Q16665	7/20	0.64

▸	HSD17B10	Q99714	6/20	0.64

▸	CYP3A4	P08684	3/20	0.64

▸	ABCB11	O95342	3/20	0.64

▸	TNF	P01375	1/20	0.64

▸	IL6	P05231	1/20	0.64

▸	SERPINA6	P08185	1/20	0.64

▸	NR3C2	P08235	1/20	0.64

▸	GLUL	P15104	1/20	0.64

▸	ADAM17	P78536	1/20	0.64

▸	GPBAR1	Q8TDU6	1/20	0.64

▸	CYP2C19	P33261	1/20	0.64

▸	LMNA	P02545	3/20	0.60

▸	ALDH1A1	P00352	2/20	0.60

▸	KMT2A	Q03164	2/20	0.60

▸	MEN1	O00255	1/20	0.60

▸	SLC29A1	Q99808	1/20	0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Meprednisone SCHEMBL10532955	0.98	PGR (0.68)	PGRARNR3C1HIF1AHSD17B10
Paramethasone SCHEMBL10532962	0.97	PGR (0.70)	PGRARNR3C1HIF1AHSD17B10
Paramethasone SCHEMBL7078196	0.94	PGR (0.76)	PGRARNR3C1HIF1AHSD17B10
Paramethasone SCHEMBL18130394	0.94	PGR (0.77)	PGRARNR3C1HIF1AHSD17B10
Methylprednisolone SCHEMBL17223638	0.91	NR3C1 (0.70)	PGRARNR3C1HIF1AHSD17B10
Paramethasone SCHEMBL13723822	0.89	PGR (0.66)	PGRARNR3C1HIF1AHSD17B10
Methylprednisolone SCHEMBL5507451	0.87	NR3C1 (0.76)	PGRARNR3C1HIF1AHSD17B10
Paramethasone SCHEMBL28086288	0.87	PGR (0.56)	PGRARNR3C1HIF1AHSD17B10
Paramethasone SCHEMBL10534685	0.86	PGR (0.81)	PGRARNR3C1HIF1AHSD17B10
Meprednisone SCHEMBL9746961	0.86	HSD17B10 (0.66)	PGRARNR3C1HIF1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009059191-A1	COMPOSITIONS AND METHODS FOR TREATMENT OF EAR CANAL INFECTION AND INFLAMMATION	EVERETT LABORATORIES, INC. (US)	2009-05-07	—	—	WO	claimed