Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketobemidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 0.72 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.72 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxypethidine SCHEMBL29966554 | 0.91 | OPRM1 (0.74) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Hydroxypethidine SCHEMBL25246 | 0.91 | OPRM1 (0.74) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Hydroxypethidine SCHEMBL317328 | 0.90 | OPRM1 (0.74) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Ketobemidone SCHEMBL29565806 | 0.88 | DRD3 (0.72) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Ketobemidone SCHEMBL24574 | 0.88 | DRD3 (0.72) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL12369084 | 0.87 | OPRM1 (0.67) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Ketobemidone SCHEMBL9706814 | 0.86 | DRD3 (0.70) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL25431 | 0.85 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL1083668 | 0.84 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL2860723 | 0.84 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |