Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clopamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 10/20 | 0.64 |
| ▸ | CA2 | P00918 | 10/20 | 0.64 |
| ▸ | CA12 | O43570 | 2/20 | 0.64 |
| ▸ | CA3 | P07451 | 2/20 | 0.64 |
| ▸ | CA4 | P22748 | 2/20 | 0.64 |
| ▸ | CA6 | P23280 | 2/20 | 0.64 |
| ▸ | CA5A | P35218 | 2/20 | 0.64 |
| ▸ | CA7 | P43166 | 2/20 | 0.64 |
| ▸ | CA9 | Q16790 | 2/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.64 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indapamide SCHEMBL7620747 | 0.85 | CA1 (0.71) | MAPTLMNAKDM4EGLAHTT | |
| Clopamide SCHEMBL124598 | 0.81 | KDM4E (1.00) | MAPTLMNAKDM4EGLAHTT | |
| Clopamide SCHEMBL1650071 | 0.81 | KDM4E (1.00) | MAPTLMNAKDM4EGLAHTT | |
| Chlorthalidone SCHEMBL29687442 | 0.80 | CA1 (1.00) | MAPTCA1CA2CA12CA3 | |
| Chlorthalidone SCHEMBL26234 | 0.80 | CA1 (1.00) | MAPTCA1CA2CA12CA3 | |
| (R)-Chlorthalidone SCHEMBL30872862 | 0.80 | CA1 (1.00) | MAPTCA1CA2CA12CA3 | |
| (R)-Chlorthalidone SCHEMBL827454 | 0.80 | CA1 (1.00) | MAPTCA1CA2CA12CA3 | |
| Chlorthalidone SCHEMBL164949 | 0.80 | CA1 (1.00) | MAPTCA1CA2CA12CA3 | |
| Chlorthalidone SCHEMBL4425734 | 0.80 | CA1 (1.00) | MAPTCA1CA2CA12CA3 | |
| Chlorthalidone SCHEMBL28520875 | 0.79 | CA1 (0.98) | MAPTCA1CA2CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |