Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.85 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.85 |
| ▸ | PLAU | P00749 | 3/20 | 0.85 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.68 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.66 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.61 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.61 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.61 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.61 |
| ▸ | F10 | P00742 | 1/20 | 0.61 |
| ▸ | PLG | P00747 | 1/20 | 0.61 |
| ▸ | S100B | P04271 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | AOC1 | P19801 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibrompropamidine SCHEMBL292947 | 0.92 | F2 (1.00) | F2ST14PLAUPRSS1 | |
| Dibrompropamidine SCHEMBL29709297 | 0.92 | F2 (1.00) | F2ST14PLAUPRSS1 | |
| Dibrompropamidine SCHEMBL21083095 | 0.91 | F2 (0.97) | F2ST14PLAUPRSS1 | |
| SCHEMBL14599538 | 0.88 | F2 (0.90) | F2ST14PLAUPRSS1 | |
| SCHEMBL597315 | 0.88 | F2 (0.90) | F2ST14PLAUPRSS1 | |
| SCHEMBL20450462 | 0.87 | F2 (0.65) | F2ST14PLAUTMPRSS2PRSS1 | |
| Propamidine SCHEMBL231060 | 0.82 | TMPRSS2 (1.00) | F2ST14PLAUTMPRSS2PRSS1 | |
| SCHEMBL12989557 | 0.82 | F2 (0.76) | F2ST14PLAUTMPRSS2PRSS1 | |
| SCHEMBL16360744 | 0.82 | F2 (0.79) | F2ST14PLAUPRSS1 | |
| SCHEMBL22824438 | 0.81 | F2 (0.78) | F2ST14PLAUPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |