Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lidoflazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR known ✓ | P42345 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.71 |
| ▸ | DRD3 | P35462 | 8/20 | 0.71 |
| ▸ | HTR2A | P28223 | 7/20 | 0.71 |
| ▸ | HRH1 | P35367 | 7/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.71 |
| ▸ | DRD2 | P14416 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lidoflazine SCHEMBL79037 | 0.84 | ADRA1A (1.00) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| SCHEMBL79038 | 0.79 | MEN1 (0.88) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| SCHEMBL10558316 | 0.79 | ADRA1A (0.80) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| SCHEMBL10683725 | 0.75 | ADRA1A (0.76) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| SCHEMBL10554577 | 0.73 | HTR2A (0.71) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| SCHEMBL10676648 | 0.73 | ADRA1A (0.73) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| Hydrochloric Acid SCHEMBL10675752 | 0.72 | ADRA1A (0.71) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| SCHEMBL10676097 | 0.71 | ADRA1A (0.70) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| SCHEMBL4500966 | 0.70 | MEN1 (0.72) | ADRA1ADRD3HTR2AHRH1OPRK1 | |
| Cadaverine Tartrate SCHEMBL10799297 | 0.70 | ADRA1A (0.68) | ADRA1ADRD3HTR2AHRH1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |