Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL892980 | 0.91 | NOTUM (0.69) | NOTUMALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL24435477 | 0.91 | NOTUM (0.69) | NOTUMALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL20271741 | 0.86 | NOTUM (0.57) | NOTUMALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL14711365 | 0.86 | MAPT (0.47) | NOTUMALDH1A1POLBMAPTHTT | |
| SCHEMBL14712094 | 0.86 | MAPT (0.47) | NOTUMALDH1A1POLBMAPTHTT | |
| SCHEMBL31401390 | 0.86 | KDM4E (0.46) | ALDH1A1MAPTSMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL30589094 | 0.85 | NOTUM (0.62) | NOTUMALDH1A1MAPTCYP2C19KMT2A | |
| SCHEMBL31175186 | 0.85 | ALDH1A1 (0.70) | ALDH1A1HTTSMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL25603132 | 0.84 | NOTUM (0.53) | NOTUMALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL29735291 | 0.84 | HSD11B1 (0.49) | NOTUMALDH1A1POLBMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301127-A | 6-Oxo-decahydro pyrrolo [1,2-a ] [1,5] diazocine and 6-oxo-decahydro-4H-pyrrolo [2,1-d ] [1,5] thiaazacine derivatives as modulators of STAT3 and STAT6 for the treatment of cancer and inflammatory conditions | 瑞克鲁迪克斯制药股份有限公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-105764887-A | Nitrogen-containing saturated heterocyclic compound | 住友化学株式会社 | 2016-07-13 | — | — | CN | disclosed |