SCHEMBL28088829

SCHEMBL28088829

CC(C)(C)c1cc([SiH](c2ccccc2)c2ccccc2)cc(C(C)(C)C)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRB P28702 6/20 0.40
RXRA P19793 5/20 0.40
RXRG P48443 2/20 0.40
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
NPC1 O15118 1/20 0.34
ALDH1A1 P00352 1/20 0.34
PLA2G1B P04054 1/20 0.34
NFKB1 P19838 1/20 0.34
CASP3 P42574 1/20 0.34
RAB9A P51151 1/20 0.34
NFKB2 Q00653 1/20 0.34
RELA Q04206 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
ATG4B Q9Y4P1 1/20 0.34
CYP3A4 P08684 2/20 0.33
MAPK1 P28482 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13897614 0.82 TSHR (0.44) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL20192381 0.82 TSHR (0.44) NPC1ALDH1A1PLA2G1BNFKB1CASP3
SCHEMBL38902 0.72 ALDH1A1 (0.40) ALDH1A1L3MBTL1CYP3A4MAPK1MAPT
Benzene SCHEMBL27873242 0.72 ALDH1A1 (0.40) ALDH1A1L3MBTL1CYP3A4MAPK1MAPT
SCHEMBL8631558 0.72 MAPK1 (0.33) ALDH1A1CYP3A4MAPK1ALOX15TSHR
SCHEMBL3181513 0.71 TSHR (0.52) NPC1ALDH1A1RAB9AMAPK1MAPT
SCHEMBL28130609 0.70 TSHR (0.37) ALDH1A1TP53TDP1TSHR
SCHEMBL24948229 0.70 ACHE (0.41) RXRBRXRANPC1ALDH1A1RAB9A
SCHEMBL7924117 0.70 MAPK1 (0.42) ALDH1A1MAPK1ALOX15HSD17B10TDP1
SCHEMBL11646120 0.70 RXRB (0.59) RXRBRXRARXRGGABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103459405-B Process for producing transition metal complex, catalyst for trimerization, process for producing 1-hexene, process for producing substituted cyclopentadiene compound (1) 住友化学株式会社 2016-09-28 CN disclosed