Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28089176 | 0.95 | PTGS2 (0.41) | ALDH1A1KDM4EMAPK1PDGFRBPDGFRA | |
| SCHEMBL15664970 | 0.81 | PTGS2 (0.42) | ALDH1A1KDM4EMAPK1PDGFRBPDGFRA | |
| SCHEMBL27934206 | 0.77 | PHF8 (0.50) | ALDH1A1KDM4EMAPK1PDGFRBPDGFRA | |
| SCHEMBL15664971 | 0.76 | PTGS2 (0.42) | PDGFRBPDGFRAPTGS2PTGS1USP2 | |
| SCHEMBL15664969 | 0.73 | PDGFRB (0.39) | ALDH1A1KDM4EMAPK1PDGFRBPDGFRA | |
| SCHEMBL28089068 | 0.73 | PTGS2 (0.43) | ALDH1A1KDM4EMAPK1PDGFRBPDGFRA | |
| SCHEMBL15664996 | 0.72 | PTGS2 (0.47) | PDGFRBPDGFRAPTGS2PTGS1USP2 | |
| SCHEMBL15664763 | 0.69 | IDO1 (0.51) | ALDH1A1KDM4EMAPK1PDGFRBPDGFRA | |
| SCHEMBL27820751 | 0.69 | GSK3B (0.44) | ALDH1A1KDM4EMAPK1PDGFRBPDGFRA | |
| SCHEMBL15664431 | 0.68 | PIK3CD (0.45) | ALDH1A1KDM4EMAPK1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753787-A | Tumor-targeting-medicine Combretastatin A4 derivatives | 南京圣和药业股份有限公司 | 2016-07-13 | — | — | CN | disclosed |