Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786952 | 0.83 | ALDH1A1 (0.48) | PDE9AGRM1GRM5LMNAALDH1A1 | |
| SCHEMBL2807304 | 0.77 | PDE9A (0.48) | PDE9ATHRBHTTESR1KDM4E | |
| SCHEMBL2788919 | 0.70 | GRM1 (0.50) | HTTKDM4EGRM1GRM5LMNA | |
| SCHEMBL13790292 | 0.69 | ALDH1A1 (0.46) | PDE9AGRM1GRM5LMNAALDH1A1 | |
| SCHEMBL31341738 | 0.69 | CYP17A1 (0.38) | PDE9ASMN1; SMN2MAPT | |
| SCHEMBL1750717 | 0.68 | HTT (0.43) | PDE9ATHRBHTTESR1KDM4E | |
| SCHEMBL13087861 | 0.65 | SMN1; SMN2 (0.55) | HTTKDM4EL3MBTL1TP53LMNA | |
| SCHEMBL7953211 | 0.65 | CDK4 (0.56) | THRBKDM4EL3MBTL1GRM1GRM5 | |
| SCHEMBL1751055 | 0.65 | ESR1 (0.42) | PDE9ATHRBHTTESR1KDM4E | |
| SCHEMBL1457129 | 0.64 | PDE9A (1.00) | PDE9ACDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118367-A2 | ANTIVIRAL PYRIMIDINES | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |