Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16981667 | 0.82 | ALDH1A1 (0.47) | PDE9AMAPTLMNAGRM1GRM5 | |
| SCHEMBL2809356 | 0.78 | GRM1 (0.54) | HTTMAPTTP53LMNAKDM4E | |
| SCHEMBL2808939 | 0.77 | PDE9A (0.47) | PDE9ATHRBL3MBTL1HTTMAPT | |
| SCHEMBL2786336 | 0.77 | GRM1 (0.55) | THRBMAPTTP53LMNAKDM4E | |
| SCHEMBL25342657 | 0.74 | CYP17A1 (0.46) | MAPT | |
| SCHEMBL839353 | 0.73 | TP53 (0.48) | THRBMAPTTP53LMNAKDM4E | |
| SCHEMBL31341680 | 0.72 | CYP17A1 (0.34) | MAPTGRM1 | |
| SCHEMBL31260942 | 0.72 | CYP17A1 (0.38) | HTTMAPTTP53LMNAKDM4E | |
| SCHEMBL25344631 | 0.72 | CYP17A1 (0.38) | HTTTP53LMNAGRM1GRM5 | |
| SCHEMBL175236 | 0.72 | ALDH1A1 (0.49) | THRBHTTMAPTTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118367-A2 | ANTIVIRAL PYRIMIDINES | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |