Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | EYA2 | O00167 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13125679 | 0.87 | MEN1 (0.46) | PTGER4MEN1KMT2APTGER2MRGPRX4 | |
| SCHEMBL6178516 | 0.81 | PTGER4 (0.50) | PTGER4MEN1KMT2APTGER2MRGPRX4 | |
| SCHEMBL6178518 | 0.81 | PTGER4 (0.50) | PTGER4MEN1KMT2APTGER2MRGPRX4 | |
| SCHEMBL2805226 | 0.80 | NOS2 (0.47) | MRGPRX4NOS2SYKP2RX4CYP2D6 | |
| Hydrochloric Acid SCHEMBL2805035 | 0.79 | NOS2 (0.46) | MRGPRX4NOS2SYKP2RX4CYP2D6 | |
| SCHEMBL3717712 | 0.79 | ALOX5 (0.42) | PTGER4MEN1KMT2APTGER2MRGPRX4 | |
| SCHEMBL6175825 | 0.77 | PTGER4 (0.47) | PTGER4MEN1KMT2APTGER2SMN1; SMN2 | |
| SCHEMBL6177071 | 0.77 | PTGER4 (0.47) | PTGER4MEN1KMT2APTGER2SMN1; SMN2 | |
| SCHEMBL6175334 | 0.77 | PTGER4 (0.47) | PTGER4MEN1KMT2APTGER2SMN1; SMN2 | |
| SCHEMBL11176242 | 0.76 | MRGPRX4 (0.47) | MRGPRX4SYKSLC6A4SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130296327-A1 | SUBSTITUTED HETEROCYLIC COMPOUNDS | INCYTE CORPORATION | 2013-11-07 | — | — | US | disclosed |
| US-20100240671-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | INCYTE CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296327-A1 | SUBSTITUTED HETEROCYLIC COMPOUNDS | HRH4, HRH2, HRH1 | PTGER4 127/4885MEN1 2221/4885KMT2A 805/4885 |
| US-20100240671-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | HRH4, HRH2, HRH1 | PTGER4 12/4885MEN1 3268/4885KMT2A 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.