Fluticasone Propionate

SCHEMBL28089754

C=C1CC2C3CCC4=CC(=O)C=CC4(C)[C@@]3(F)C(O)CC2(C)[C@@]1(O)C(=O)COC(C)=O.CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluticasone Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	12/20	0.70

▸	CYP3A4	P08684	6/20	0.70

▸	PGR	P06401	5/20	0.70

▸	NR1I2	O75469	3/20	0.70

▸	ADORA3	P0DMS8	3/20	0.70

▸	AR	P10275	3/20	0.70

▸	NR3C2	P08235	1/20	0.70

▸	MAPT	P10636	2/20	0.61

▸	DRD2	P14416	1/20	0.61

▸	OPRD1	P41143	1/20	0.61

▸	HIF1A	Q16665	4/20	0.61

▸	SMN1; SMN2	Q16637	3/20	0.61

▸	ALDH1A1	P00352	1/20	0.61

▸	CYP1A2	P05177	1/20	0.61

▸	LMNA	P02545	3/20	0.57

▸	USP2	O75604	2/20	0.57

▸	CYP2C9	P11712	2/20	0.57

▸	MLNR	O43193	1/20	0.57

▸	ABCB11	O95342	1/20	0.57

▸	CYP3A5	P20815	1/20	0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fluticasone Propionate SCHEMBL15568062	0.86	CYP3A4 (0.77)	NR3C1CYP3A4PGRNR1I2ADORA3
Beclomethasone Dipropionate SCHEMBL8538440	0.84	NR3C1 (0.74)	NR3C1CYP3A4PGRNR1I2ADORA3
SCHEMBL6685138	0.84	NR3C1 (0.63)	NR3C1CYP3A4PGRNR1I2ADORA3
Fluticasone Propionate SCHEMBL4283	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR1I2ADORA3
Fluticasone Propionate SCHEMBL416179	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR1I2ADORA3
Fluticasone Propionate SCHEMBL15325049	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR1I2ADORA3
Fluticasone Propionate SCHEMBL14343427	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR1I2ADORA3
Fluticasone Propionate SCHEMBL13026160	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR1I2ADORA3
Fluticasone Propionate SCHEMBL191134	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR1I2ADORA3
Fluticasone Propionate SCHEMBL13602403	0.83	NR3C1 (1.00)	NR3C1CYP3A4PGRNR1I2ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-106278999-B	S1P regulator	比奥根MA公司	2019-10-25	—	—	CN	disclosed
CN-106278999-A	S1p regulator	比奥根MA公司	2017-01-04	—	—	CN	disclosed
CN-103533835-B	S1P modulators	比奥根MA公司	2016-08-24	—	—	CN	disclosed