Beclomethasone Dipropionate

SCHEMBL8538440

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C.CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Beclomethasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	12/20	0.74

▸	PGR	P06401	6/20	0.74

▸	CYP3A4	P08684	6/20	0.74

▸	ADORA3	P0DMS8	4/20	0.74

▸	AR	P10275	4/20	0.74

▸	NR1I2	O75469	3/20	0.74

▸	NR3C2	P08235	1/20	0.74

▸	USP2	O75604	4/20	0.73

▸	HIF1A	Q16665	3/20	0.73

▸	CHRM1	P11229	2/20	0.73

▸	CNR1	P21554	1/20	0.73

▸	TBXA2R	P21731	1/20	0.73

▸	MAPT	P10636	2/20	0.69

▸	DRD2	P14416	1/20	0.69

▸	OPRD1	P41143	1/20	0.69

▸	ADRA1A	P35348	1/20	0.64

▸	LMNA	P02545	2/20	0.61

▸	SMN1; SMN2	Q16637	2/20	0.61

▸	MLNR	O43193	1/20	0.61

▸	ABCB11	O95342	1/20	0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Beclomethasone Dipropionate SCHEMBL8538442	0.94	NR3C1 (0.68)	NR3C1PGRCYP3A4ADORA3AR
Fluticasone Propionate SCHEMBL18691941	0.91	NR3C1 (0.73)	NR3C1PGRCYP3A4ADORA3AR
Beclomethasone Dipropionate SCHEMBL4461051	0.88	NR3C1 (0.90)	NR3C1PGRCYP3A4ADORA3AR
Mometasone Furoate SCHEMBL1599330	0.88	NR3C1 (0.73)	NR3C1PGRCYP3A4ADORA3AR
Betamethasone Dipropionate SCHEMBL18304670	0.87	PGR (0.82)	NR3C1PGRCYP3A4ADORA3AR
SCHEMBL11237004	0.87	CYP3A4 (0.75)	NR3C1PGRCYP3A4ADORA3AR
Fluticasone Propionate SCHEMBL416179	0.86	NR3C1 (1.00)	NR3C1PGRCYP3A4ADORA3AR
Fluticasone Propionate SCHEMBL15944858	0.86	NR3C1 (1.00)	NR3C1PGRCYP3A4ADORA3AR
Fluticasone Propionate SCHEMBL15325049	0.86	NR3C1 (1.00)	NR3C1PGRCYP3A4ADORA3AR
Fluticasone Propionate SCHEMBL13602403	0.86	NR3C1 (1.00)	NR3C1PGRCYP3A4ADORA3AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0616524-B1	MEDICAMENTS	GLAXO GROUP LTD (GB)	1998-10-07	—	—	EP	claimed