Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 6/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | ITK | Q08881 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519615 | 0.72 | SRC (0.70) | SRCGSK3BJAK3MAP2K7AURKA | |
| SCHEMBL5946883 | 0.72 | NR3C2 (0.44) | NR3C2 | |
| SCHEMBL4103284 | 0.71 | TGM2 (0.76) | JAK3MAP2K7AURKATGM2BTK | |
| SCHEMBL14982753 | 0.71 | SRC (0.57) | SRCGSK3BJAK3MAP2K7AURKA | |
| SCHEMBL7520883 | 0.71 | SRC (1.00) | SRCEGFR | |
| SCHEMBL12807117 | 0.70 | JAK3 (0.59) | JAK3MAP2K7AURKATGM2BTK | |
| SCHEMBL21469043 | 0.69 | TGM2 (0.59) | SRCJAK3MAP2K7AURKATGM2 | |
| SCHEMBL17660300 | 0.69 | EPHB4 (0.61) | SRCJAK3MAP2K7AURKATGM2 | |
| SCHEMBL24150540 | 0.69 | JAK3 (0.60) | SRCJAK3MAP2K7AURKATGM2 | |
| SCHEMBL30190551 | 0.69 | JAK3 (0.60) | SRCJAK3MAP2K7AURKATGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105777756-A | Heteroaryl compound and application thereof in medicines | 广东东阳光药业有限公司 | 2016-07-20 | — | — | CN | disclosed |