Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.50 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL31070222 | 0.94 | — | — | |
| D-Aspartate SCHEMBL31235712 | 0.94 | GRIK1 (0.56) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL3231 | 0.94 | — | — | |
| Aspartic Acid SCHEMBL1526976 | 0.94 | GRIK1 (0.56) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| D-Aspartate SCHEMBL145539 | 0.94 | — | — | |
| Aspartic Acid SCHEMBL11065185 | 0.94 | GRIK1 (0.56) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL11065189 | 0.94 | GRIK1 (0.56) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL996424 | 0.94 | GRIK1 (0.56) | PTGS1SLC7A11GRIK1GRIK2GRM1 | |
| Aspartic Acid SCHEMBL3230 | 0.94 | — | — | |
| Aspartic Acid SCHEMBL31673497 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355771-B1 | MODIFIED BY MERCAPTOALKYLAMINE; CORROSION RESISTANCE, ANTISCALING AGENTS | NIPPON SHOKUBAI CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| EP-0980883-A1 | Modified polyaspartic acid, method for production thereof and use therefor | Nippon Shokubai Co., Ltd. (JP) | 2000-02-23 | — | — | EP | disclosed |