Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetaminophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 1.00 |
| ▸ | BRD4 | O60885 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | CA1 | P00915 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 1.00 |
| ▸ | MB | P02144 | 1/20 | 1.00 |
| ▸ | CYP1A1 | P04798 | 1/20 | 1.00 |
| ▸ | CA3 | P07451 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | RARG | P13631 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX5AP | P20292 | 1/20 | 1.00 |
| ▸ | CA4 | P22748 | 1/20 | 1.00 |
| ▸ | CA7 | P43166 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetaminophen SCHEMBL8937727 | 1.00 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL3480 | 1.00 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8197085 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL20541508 | 0.98 | ALDH1A1 (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL31738441 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL10325382 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8959271 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL5081499 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8207526 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL29013939 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113651713-B | Synthesis method of high-purity 2-nitro-4-acetamido anisole | 宁夏中盛新科技有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-117303834-A | Cement-based high-ductility reinforced composite material for seismic belt building and preparation method thereof | 唐山盾石干粉建材有限责任公司 | 2023-12-29 | — | — | CN | claimed |
| CN-116903487-A | Method and equipment for continuously preparing 2-nitro-4-acetamido anisole | 山东嘉信新材料有限公司 | 2023-10-20 | — | — | CN | claimed |
| US-20210283066-A1 | SKIN CONTACT ADHESIVE AND METHODS FOR ITS PREPARATION AND USE | DOW SILICONES CORPORATION | 2021-09-16 | — | — | US | claimed |
| US-20210284840-A1 | COPOLYMER COMPOSITION FOR COATING AND ADHESIVE APPLICATIONS | DOW SILICONES CORP (US) | 2021-09-16 | — | — | US | claimed |
| EP-3515560-A1 | COPOLYMER COMPOSITION FOR COATING AND ADHESIVE APPLICATIONS | Dow Corning Corporation (US) | 2019-07-31 | — | — | EP | claimed |
| EP-3515959-A1 | SKIN CONTACT ADHESIVE AND METHODS FOR ITS PREPARATION AND USE | Dow Silicones Corporation (US) | 2019-07-31 | — | — | EP | claimed |
| CN-109843380-A | Copolymer compositions for coating and adhesive applications | 美国陶氏有机硅公司 | 2019-06-04 | — | — | CN | claimed |
| CN-109715692-A | Skin contact adhesive and its preparation and application | 美国陶氏有机硅公司 | 2019-05-03 | — | — | CN | claimed |
| WO-2018052645-A1 | SKIN CONTACT ADHESIVE AND METHODS FOR ITS PREPARATION AND USE | DOW CORNING CORPORATION (US) | 2018-03-22 | — | — | WO | claimed |
| WO-2018052646-A1 | COPOLYMER COMPOSITION FOR COATING AND ADHESIVE APPLICATIONS | DOW CORNING CORPORATION (US) | 2018-03-22 | — | — | WO | claimed |
| US-20170252446-A1 | USE OF MESO- AND NANOPOROUS MATERIAL FOR SURFACTANT TRAPPING IN NANOPARTICLE SUSPENSIONS | BIOCORRX, INC. | 2017-09-07 | — | — | US | claimed |
| CN-103648486-A | Sustained release paracetamol formulations | GLAXOSMITHKLINE LLC | 2014-03-19 | — | — | CN | claimed |
| CN-113651713-B | Synthesis method of high-purity 2-nitro-4-acetamido anisole | 宁夏中盛新科技有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-116621885-B | Recycling treatment method of 2-amino-4-acetamido anisole production wastewater | 宁夏中盛新科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117772103-A | Preparation device and preparation method of 3-nitro-4-methoxy acetanilide | 杭州吉华江东化工有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-4893253-A | Method for analyzing intact capsules and tablets by near-infrared reflectance spectrometry | INDIANA UNIVERSITY FOUNDATION (US) | 1990-01-09 | — | — | US | disclosed |
| EP-0343573-A1 | Medicines containing 1,2-dithiol-3-thion-S-oxyde compounds | Kali-Chemie Pharma GmbH (DE) | 1989-11-29 | — | — | EP | disclosed |
| US-4873249-A | 2,4-DIAMINO-5-(3,4-DIMETHOXY-BENZYL)-PYRIMIDINE; ANALGESIC OR ANTINFLAMMATORY AGENT | EGIS GYOGYSZERGYAR (HU) | 1989-10-10 | — | — | US | disclosed |
| US-4727074-A | ANGINA PECTORIS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1988-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210284840-A1 | COPOLYMER COMPOSITION FOR COATING AND ADHESIVE APPLICATIONS | EPM2A, ILK, CUTA | KMT2A 1608/4885ALDH1A1 820/4885MAPT 1078/4885 |
| US-20210283066-A1 | SKIN CONTACT ADHESIVE AND METHODS FOR ITS PREPARATION AND USE | CUTA, COL1A1, ITGB7 | KMT2A 1474/4885ALDH1A1 960/4885MAPT 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.