Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetaminophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 1.00 |
| ▸ | BRD4 | O60885 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | CA1 | P00915 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 1.00 |
| ▸ | MB | P02144 | 1/20 | 1.00 |
| ▸ | CYP1A1 | P04798 | 1/20 | 1.00 |
| ▸ | CA3 | P07451 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | RARG | P13631 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX5AP | P20292 | 1/20 | 1.00 |
| ▸ | CA4 | P22748 | 1/20 | 1.00 |
| ▸ | CA7 | P43166 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetaminophen SCHEMBL8937727 | 1.00 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL252939 | 1.00 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8197085 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL20541508 | 0.98 | ALDH1A1 (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL31738441 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL10325382 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8959271 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL5081499 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL8207526 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 | |
| Acetaminophen SCHEMBL29013939 | 0.98 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 178751 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146216-A1 | MULTI-USE HEAVY-DUTY CLEANING AND DEGREASING COMPOSITION IN A SOLID DOSE | ECOLAB USA INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| EP-4746974-A1 | GP130 ANTIGEN-BINDING ANTIBODIES | VVB Bio Pte. Ltd. (SG) | 2026-05-27 | — | — | EP | claimed |
| EP-4590675-B1 | HETEROCYCLIC SIK INHIBITORS | PFIZER (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4541416-B1 | ADAPTIVE CHRONIC PAIN RELIEF VIA IMPLANTED ELECTRICAL NEUROSTIMULATION | BOSTON SCIENT NEUROMODULATION CORP (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4747278-A1 | DSFV AS AN IGG FRAGMENT FORMAT AND METHODS OF PRODUCTION AND LABELLING THEREOF | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | claimed |
| US-12636268-B2 | CXCL8 inhibitors for use in the treatment of COVID-19 | DOMPE' FARMACEUTICI SPA (IT) | 2026-05-26 | — | — | US | claimed |
| CN-121574086-B | Dicyano-isophorone derivative, preparation method thereof and application of dicyano-isophorone derivative as near infrared fluorescent probe for detecting COX-2 | BINZHOU MEDICAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-117105746-B | Synthesis method of hydroquinone | Ningxia Yuankang Pharmaceutical Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-4036228-A | Osmotic dispenser with gas generating means | ALZA CORPORATION (US) | 1977-07-19 | — | — | US | claimed |
| US-4022251-A | Jacquard machine having reciprocating griffes and lifting wires | SULZER BROTHERS LIMITED (CH) | 1977-05-10 | — | — | US | claimed |
| US-4013785-A | N-ACETYL-P-AMINOPHENYL, ANALGESIC, ANTIPYRETIC | BRISTOL-MYERS COMPANY (US) | 1977-03-22 | — | — | US | claimed |
| US-4009270-A | WATER SOLUBLE CAROTENOID | THE UNIVERSITY OF VIRGINIA (US) | 1977-02-22 | — | — | US | claimed |
| US-3987170-A | ANALGESICS AND ANTIPYRETICS | SOCIETE BOTTU (FR) | 1976-10-19 | — | — | US | claimed |
| US-3975519-A | CAROTENOID | UNIVERSITY OF VIRGINIA (US) | 1976-08-17 | — | — | US | claimed |
| US-3968140-A | PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1976-07-06 | — | — | US | claimed |
| US-3965261-A | CAROTENOID | UNIVERSITY OF VIRGINIA (US) | 1976-06-22 | — | — | US | claimed |
| US-3956490-A | ANALGESICS, SEDATIVES, ANTIINFLAMMATORY AGENTS | INTERX RESEARCH CORPORATION (US) | 1976-05-11 | — | — | US | claimed |
| US-3952048-A | PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1976-04-20 | — | — | US | claimed |