Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.97 |
| ▸ | HTR2C | P28335 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 6/20 | 0.65 |
| ▸ | HTR1D | P28221 | 1/20 | 0.65 |
| ▸ | HTR1B | P28222 | 1/20 | 0.65 |
| ▸ | HTR3A | P46098 | 3/20 | 0.64 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.64 |
| ▸ | HTR3B | O95264 | 2/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | HTR7 | P34969 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669070 | 1.00 | ADRB1 (0.97) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL379449 | 0.98 | ADRB1 (1.00) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL7838014 | 0.98 | ADRB1 (1.00) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| Bromide SCHEMBL27617608 | 0.97 | ADRB1 (0.97) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7757785 | 0.97 | ADRB1 (0.97) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| Bromide SCHEMBL4875933 | 0.97 | ADRB1 (0.97) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1706127 | 0.97 | ADRB1 (0.97) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1024982 | 0.97 | ADRB1 (0.97) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL4526848 | 0.92 | ADRB1 (0.88) | ADRB1HTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL11074672 | 0.85 | ADRB1 (0.76) | ADRB1NPC1MAPTDRD2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103102436-B | Liquid polymers and the synthesis of functionalized polymeric | 株式会社普利司通 | 2016-08-03 | — | — | CN | claimed |