Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 0.67 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | HTR1D | P28221 | 1/20 | 0.67 |
| ▸ | HTR1B | P28222 | 1/20 | 0.67 |
| ▸ | HTR3A | P46098 | 3/20 | 0.66 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.66 |
| ▸ | HTR3B | O95264 | 2/20 | 0.66 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.66 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.66 |
| ▸ | HTR7 | P34969 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379449 | 1.00 | ADRB1 (1.00) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| Bromide SCHEMBL27617608 | 0.98 | ADRB1 (0.97) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| Piperazine SCHEMBL28092166 | 0.98 | ADRB1 (0.97) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1706127 | 0.98 | ADRB1 (0.97) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| SCHEMBL5669070 | 0.98 | ADRB1 (0.97) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| Bromide SCHEMBL4875933 | 0.98 | ADRB1 (0.97) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1024982 | 0.98 | ADRB1 (0.97) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7757785 | 0.98 | ADRB1 (0.97) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| SCHEMBL4526848 | 0.94 | ADRB1 (0.88) | ADRB1HTR1AHTR2CHTR1DHTR1B | |
| SCHEMBL11074672 | 0.87 | ADRB1 (0.76) | ADRB1NPC1MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445811-B1 | Nitrogen-containing heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-14 | — | — | EP | claimed |
| EP-0454501-B1 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | SANKYO CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0839812-A1 | Preparation of benzylthiazolidine derivatives | Sankyo Company Limited (JP) | 1998-05-06 | — | — | EP | disclosed |
| EP-0443568-B1 | Fused thiophene derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-12 | — | — | EP | disclosed |
| EP-0445811-B1 | Nitrogen-containing heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-14 | — | — | EP | disclosed |
| US-5387596-A | Treating arteriosclerosis | SANKYO COMPANY, LIMITED (JP) | 1995-02-07 | — | — | US | disclosed |
| US-5304565-A | Angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| US-5284661-A | 4-Oxo-7-(biphenyl-4-yl)thieno(2,3-b)pyridines as antagonist of angiotensin II; hypertensive agents, cardiovascular disorders and strokes | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | disclosed |
| EP-0445811-A2 | Nitrogen-containing heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-09-11 | — | — | EP | disclosed |
| EP-0443568-A1 | Fused thiophene derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |