Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805119 | 0.84 | KDM4E (0.40) | KDM4EMT-CO2LRRK2TAS1R3TAS1R1 | |
| SCHEMBL2795820 | 0.82 | LRRK2 (0.36) | KDM4EMT-CO2CYP1A2LRRK2TAS1R3 | |
| Trifluoroacetic Acid SCHEMBL185630 | 0.81 | LRRK2 (0.40) | KDM4ELRRK2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL2810373 | 0.80 | CYP1A2 (0.41) | KDM4ECYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL186470 | 0.79 | KDM4E (0.51) | KDM4EMT-CO2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6055534 | 0.78 | HTT (0.49) | KDM4ECYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL2806180 | 0.75 | BDKRB1 (0.49) | LRRK2NAMPT | |
| SCHEMBL2806814 | 0.75 | LRRK2 (0.42) | CYP1A2CYP2C19LRRK2RAB9ANPC1 | |
| SCHEMBL22979636 | 0.73 | TAS1R3 (0.57) | KDM4ECYP1A2TSHRTAS1R3TAS1R1 | |
| SCHEMBL20552263 | 0.72 | TEAD1 (0.50) | KDM4ELRRK2TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131075-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-23 | — | — | US | disclosed |
| US-20100240669-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131075-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | KDM4E 4133/4885MT-CO2 1519/4885CYP1A2 892/4885 |
| US-20100240669-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | KDM4E 4133/4885MT-CO2 1519/4885CYP1A2 892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.