Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.39 |
| ▸ | ITGAV | P06756 | 3/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL185638 | 0.83 | TAS2R14 (0.46) | ITGB3ITGB1ITGA5ITGAVITGB5 | |
| Trifluoroacetic Acid SCHEMBL185394 | 0.81 | CXCR2 (0.40) | LRRK2ITGB3ITGB1ITGA5ITGAV | |
| SCHEMBL2809520 | 0.81 | KDM4E (0.41) | LRRK2TAS1R3TAS1R1TAS1R2KDM4E | |
| Trifluoroacetic Acid SCHEMBL185495 | 0.78 | TAS2R14 (0.41) | LRRK2ITGB3ITGB1ITGA5ITGAV | |
| Trifluoroacetic Acid SCHEMBL186078 | 0.78 | LRRK2 (0.40) | LRRK2ITGB3ITGB1ITGA5ITGAV | |
| SCHEMBL6055534 | 0.76 | HTT (0.49) | LRRK2TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL20552263 | 0.75 | TEAD1 (0.50) | LRRK2TAS1R3TAS1R1TAS1R2KDM4E | |
| Trifluoroacetic Acid SCHEMBL14856770 | 0.75 | ALDH1A1 (0.46) | ITGB3ITGB1ITGA5ITGAVITGB5 | |
| SCHEMBL2805119 | 0.75 | KDM4E (0.40) | LRRK2TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL2795820 | 0.73 | LRRK2 (0.36) | LRRK2TAS1R3TAS1R1TAS1R2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131075-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-23 | — | — | US | disclosed |
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| US-20100240669-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131075-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | LRRK2 2304/4885ITGB3 2114/4885ITGB1 1839/4885 |
| US-20100240669-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | LRRK2 2304/4885ITGB3 2114/4885ITGB1 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.