Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809557 | 0.88 | METAP2 (0.38) | LRRK2METAP2CXCR2ALDH1A1CCR2 | |
| SCHEMBL2810373 | 0.84 | CYP1A2 (0.41) | LRRK2CXCR2ALDH1A1NPC1POLB | |
| SCHEMBL2805119 | 0.83 | KDM4E (0.40) | LRRK2METAP2AKT2ALDH1A1ROCK2 | |
| SCHEMBL2805481 | 0.78 | AKT2 (0.39) | LRRK2METAP2AKT2ALDH1A1NAMPT | |
| SCHEMBL2804886 | 0.78 | AKT2 (0.39) | LRRK2METAP2AKT2ALDH1A1NAMPT | |
| SCHEMBL196872 | 0.76 | BDKRB1 (0.40) | LRRK2NAMPTMAP3K8 | |
| Trifluoroacetic Acid SCHEMBL185394 | 0.75 | CXCR2 (0.40) | LRRK2CXCR2ROCK2HDAC6 | |
| SCHEMBL2808648 | 0.74 | AKT2 (0.39) | METAP2AKT2ALDH1A1ROCK2NPC1 | |
| Trifluoroacetic Acid SCHEMBL2805210 | 0.74 | AKT2 (0.36) | LRRK2METAP2AKT2NAMPTNPC1 | |
| SCHEMBL2795820 | 0.72 | LRRK2 (0.36) | LRRK2METAP2ROCK2NAMPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131075-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-23 | — | — | US | disclosed |
| US-20100240669-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131075-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | LRRK2 2304/4885METAP2 3017/4885AKT2 3922/4885 |
| US-20100240669-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | LRRK2 2304/4885METAP2 3017/4885AKT2 3922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.