Quinoline

Quinoline

SCHEMBL28096081

O=CO.c1ccc2ncccc2c1.c1ccc2ncccc2c1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.74
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CASP1 P29466 2/20 0.48
CASP7 P55210 1/20 0.48
NPC1 O15118 2/20 0.47
POLB P06746 2/20 0.47
RAB9A P51151 1/20 0.47
CYP3A4 P08684 2/20 0.45
KDM4E B2RXH2 2/20 0.44
MAPT P10636 2/20 0.44
HTT P42858 3/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C19 P33261 1/20 0.44
NR4A2 P43354 1/20 0.44
TP53 P04637 1/20 0.44
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
TSHR P16473 1/20 0.44
ATM Q13315 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL4721637 1.00 ALDH1A1 (0.74) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL29354528 1.00 ALDH1A1 (0.74) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL28425004 0.98 ALDH1A1 (0.71) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL27889103 0.98 ALDH1A1 (0.71) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL28096623 0.89 ALDH1A1 (0.77) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL27700047 0.89 ALDH1A1 (0.85) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL27832156 0.87 ALDH1A1 (0.74) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL27851343 0.87 ALDH1A1 (0.74) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL27925298 0.87 ALDH1A1 (0.74) ALDH1A1MEN1KMT2ACASP1CASP7
Quinoline SCHEMBL28166944 0.87 ALDH1A1 (0.74) ALDH1A1MEN1KMT2ACASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113620883-B Preparation method of semi-proton type compound, product and application thereof 西南大学 2023-04-11 CN disclosed
CN-113620883-A Preparation method of semi-proton type compound, product and application thereof 西南大学 2021-11-09 CN disclosed
CN-110041427-A Anti- hepcidin antibody and application thereof 本质生命科学有限公司 2019-07-23 CN disclosed
CN-105263514-B Anti-hepcidin antibodies and uses thereof 本质生命科学有限公司 2019-04-26 CN disclosed
CN-108472368-A Novel anti-UPK 1B antibodies and methods of use 艾伯维施特姆森特克斯有限责任公司 2018-08-31 CN disclosed
CN-107580453-A The enzyme' s catalysis of soluble glucan fiber 纳幕尔杜邦公司 2018-01-12 CN disclosed
CN-106661599-A Enzymatic synthesis of soluble glucan fibers 纳幕尔杜邦公司 2017-05-10 CN disclosed
CN-106661559-A Enzymatic synthesis of soluble glucan fiber 纳幕尔杜邦公司 2017-05-10 CN disclosed
CN-106535653-A Enzymatic synthesis of soluble glucan fibers 纳幕尔杜邦公司 2017-03-22 CN disclosed
CN-106536569-A Enzymatic synthesis of soluble glucan fiber 纳幕尔杜邦公司 2017-03-22 CN disclosed
CN-106442484-A Method for detecting hydrolase activity 南京理工大学 2017-02-22 CN disclosed
CN-106414506-A Enzymatic synthesis of soluble glucan fibers 纳幕尔杜邦公司 2017-02-15 CN disclosed
CN-103890009-B Interleukin-31 monoclonal antibody 硕腾服务有限责任公司 2017-02-15 CN disclosed
CN-106231899-A For processing reagent and the method for pathogen 赫希玛有限公司 2016-12-14 CN disclosed
CN-105963305-A Medicine composition containing tyrosine kinase inhibitor and application thereof in preparation of anti-tumor transfer medicines 福州大学 2016-09-28 CN disclosed
CN-104478723-B Synthesis naphthalene derivative and the method for benzo-heterocycle compound 陕西师范大学 2016-08-24 CN disclosed