Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28096513 | 1.00 | TSHR (0.43) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL8601709 | 0.97 | TSHR (0.46) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL1357485 | 0.95 | TSHR (0.48) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Hydrochloric Acid SCHEMBL30473262 | 0.92 | TSHR (0.46) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL31215166 | 0.90 | TSHR (0.43) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL9007220 | 0.78 | TP53 (0.48) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL6702760 | 0.77 | TP53 (0.42) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL6700844 | 0.77 | TP53 (0.42) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL29637107 | 0.76 | TP53 (0.46) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL4449680 | 0.76 | MEN1 (0.36) | TSHRALDH1A1TP53TRPA1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107892306-B | A kind of preparation method of low partial size high water absorption Silica Using for Toothpaste | 广州市飞雪材料科技有限公司 | 2019-11-15 | — | — | CN | claimed |
| CN-106900733-B | A kind of supermolecule fungicide and preparation method thereof and method for disinfection | 中国科学院化学研究所 | 2019-08-23 | — | — | CN | claimed |
| CN-107353952-B | A kind of coal water slurry dispersing agent and preparation method thereof | 扬州市立达树脂有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-109276569-A | A kind of stable crystal form pharmaceutical composition and its preparation method and application | 四川海思科制药有限公司 | 2019-01-29 | — | — | CN | claimed |
| CN-108676289-A | A kind of antifouling anti-corrosion sewage disposal special PVC pipeline and preparation method thereof | 安庆市洁达塑业有限公司 | 2018-10-19 | — | — | CN | claimed |
| CN-107892306-A | A kind of preparation method of low particle diameter high water absorption Silica Using for Toothpaste | 广州市飞雪材料科技有限公司 | 2018-04-10 | — | — | CN | claimed |
| CN-107353952-A | A kind of coal water slurry dispersing agent and preparation method thereof | 常州金艺广告传媒有限公司 | 2017-11-17 | — | — | CN | claimed |
| CN-107129647-A | A kind of fire-retardant degradable environmental protection macromolecule foamed material and preparation method thereof | 广西南宁桂尔创环保科技有限公司 | 2017-09-05 | — | — | CN | claimed |
| CN-107083667-A | A kind of preparation method of antibacterial and mouldproof eider down | 安徽三祥羽毛股份有限公司 | 2017-08-22 | — | — | CN | claimed |
| CN-106900733-A | A kind of supermolecule bactericide and preparation method thereof and method for disinfection | 中国科学院化学研究所 | 2017-06-30 | — | — | CN | claimed |
| CN-106893165-A | A kind of environment-friendly type macromolecule foamed material | 广西丰达三维科技有限公司 | 2017-06-27 | — | — | CN | claimed |
| CN-106893179-A | A kind of sound insulation type material, preparation method and applications | 广西丰达三维科技有限公司 | 2017-06-27 | — | — | CN | claimed |
| CN-106867147-A | A kind of foamed material and its application | 广西丰达三维科技有限公司 | 2017-06-20 | — | — | CN | claimed |
| CN-106832593-A | A kind of printing consumables and preparation method thereof | 广西丰达三维科技有限公司 | 2017-06-13 | — | — | CN | claimed |
| CN-106430697-A | Method for treating tin-plating sewage | 吴小慧 | 2017-02-22 | — | — | CN | claimed |
| CN-106430754-A | Fast treating method for copper mine waste water | 吴小慧 | 2017-02-22 | — | — | CN | claimed |
| CN-106430698-A | Special water purifying agent for chloroprene rubber production and wastewater treatment method | 张海棠 | 2017-02-22 | — | — | CN | claimed |
| CN-106242111-A | A kind of for processing the cleanser containing Mercury sewage and method of wastewater treatment | 吴小慧 | 2016-12-21 | — | — | CN | claimed |
| CN-106186473-A | A kind of cleanser for processing nickeliferous sewage and method of wastewater treatment | 吴小慧 | 2016-12-07 | — | — | CN | claimed |
| CN-105870545-A | Electrolyte corrosion inhibitor, aluminum-air battery electrolyte and preparation method of aluminum-air battery electrolyte | 中南大学 | 2016-08-17 | — | — | CN | claimed |