Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.37 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28096512 | 0.97 | TSHR (0.43) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL28096513 | 0.97 | TSHR (0.43) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL1357485 | 0.97 | TSHR (0.48) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Hydrochloric Acid SCHEMBL30473262 | 0.94 | TSHR (0.46) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL31215166 | 0.92 | TSHR (0.43) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL9007220 | 0.80 | TP53 (0.48) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL6700844 | 0.79 | TP53 (0.42) | TSHRALDH1A1TP53TRPA1CALM1 | |
| Bromide SCHEMBL6702760 | 0.79 | TP53 (0.42) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL29637107 | 0.78 | TP53 (0.46) | TSHRALDH1A1TP53TRPA1CALM1 | |
| SCHEMBL4449680 | 0.78 | MEN1 (0.36) | TSHRALDH1A1TP53TRPA1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102391660-A | Green multifunctional composite additive for wood-plastic composite material and preparation method thereof | GUANGDONG DEMAY BIOLOG TECHNOLOGY CO LTD | 2012-03-28 | — | — | CN | disclosed |
| EP-0536036-B1 | Cardioprotective tocopherol analogs | MERRELL PHARMA INC (US) | 1998-02-25 | — | — | EP | disclosed |
| EP-0536036-A1 | Cardioprotective tocopherol analogs | MERRELL PHARMACEUTICALS INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| EP-0535283-A1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-04-07 | — | — | EP | disclosed |