Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3060705 | 0.87 | MAPT (0.51) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL9956671 | 0.85 | ACE (0.59) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL2727571 | 0.85 | ACE (0.59) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL3222312 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL2728490 | 0.85 | KLK5 (0.55) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL3216191 | 0.85 | MAPT (0.49) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL2727573 | 0.85 | ACE (0.59) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL3222299 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL29643038 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2RAB9AALOX5NPC1 | |
| SCHEMBL29469017 | 0.85 | ACE (0.59) | MAPTSMN1; SMN2RAB9AALOX5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110354128-A | Pyrimidine FGFR4 inhibitors | 卫材R&D管理有限公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-105899490-B | Pyrimidine FGFR4 Inhibitors | 卫材R&D管理有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-107295798-A | Benzazepine dicarboxamide compound | 豪夫迈·罗氏有限公司 | 2017-10-24 | — | — | CN | disclosed |
| CN-105899490-A | Pyrimidine fgfr4 inhibitors | 卫材R&D管理有限公司 | 2016-08-24 | — | — | CN | disclosed |