Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28003614 | 0.88 | MAPK14 (0.42) | NR3C2MAPK14KIF11SLC5A1MAPK8 | |
| SCHEMBL28097352 | 0.87 | NR3C2 (0.52) | NR3C2MAPK14HSP90AA1MAPK8MAPK9 | |
| SCHEMBL15556243 | 0.83 | NR3C2 (0.53) | NR3C2MAPK14HSP90AA1MAPK8MAPK9 | |
| SCHEMBL17075430 | 0.80 | PIM1 (0.47) | NR3C2MAPK14HSP90AA1SMN1; SMN2 | |
| SCHEMBL28097405 | 0.78 | MEN1 (0.50) | NR3C2MAPK14SLC5A1MAPK8MAPK9 | |
| SCHEMBL15559871 | 0.76 | MAPK14 (0.44) | NR3C2MAPK14HSP90AA1 | |
| SCHEMBL27618711 | 0.75 | NR3C2 (0.55) | NR3C2MAPK14HSP90AA1MAPK8MAPK9 | |
| SCHEMBL17086640 | 0.73 | SMN1; SMN2 (0.50) | NR3C2MAPK14HSP90AA1SMN1; SMN2 | |
| SCHEMBL15560513 | 0.72 | KDM5A (0.50) | NR3C2MAPK14HSP90AA1 | |
| SCHEMBL26821713 | 0.71 | KIF11 (0.73) | KIF11GLO1AGXTDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | claimed |
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | disclosed |