Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28097403 | 0.89 | NR3C2 (0.51) | MEN1KMT2AMAPK9MAPK10MAPK8 | |
| SCHEMBL17086614 | 0.88 | MEN1 (0.48) | MEN1KMT2AMAPK9MAPK10MAPK8 | |
| SCHEMBL28097404 | 0.86 | NR3C1 (0.50) | MEN1KMT2AMAPK9MAPK10MAPK8 | |
| SCHEMBL28097351 | 0.82 | NR3C2 (0.46) | MEN1KMT2AMAPK9MAPK10MAPK8 | |
| SCHEMBL28097416 | 0.82 | KDM5A (0.49) | MEN1KMT2AMAPK9MAPK10MAPK8 | |
| SCHEMBL26831184 | 0.79 | KIF11 (0.59) | MAPTALDH1A1NPBWR1PTPN5 | |
| SCHEMBL15560352 | 0.78 | PIM1 (0.47) | MEN1KMT2AMAPK9MAPK10MAPK8 | |
| SCHEMBL28097406 | 0.78 | NR3C2 (0.51) | MAPK9MAPK10MAPK8NR3C2ALDH1A1 | |
| SCHEMBL28097353 | 0.78 | NR3C2 (0.48) | MAPK9MAPK10MAPK8NR3C2SLC5A1 | |
| SCHEMBL17086629 | 0.76 | MAPT (0.54) | MEN1KMT2AMAPK9MAPK10MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | claimed |
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | disclosed |