Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28097406 | 0.90 | NR3C2 (0.51) | NR3C2MAPK14NT5EKDM5AKDM4C | |
| SCHEMBL15556452 | 0.88 | KDM5A (0.52) | NR3C2MAPK14NT5EKDM5AKDM4C | |
| SCHEMBL28097404 | 0.83 | NR3C1 (0.50) | NR3C2MAPK14KDM5AKDM4CKDM5B | |
| SCHEMBL15559871 | 0.82 | MAPK14 (0.44) | NR3C2MAPK14KDM5AKDM4CKDM5B | |
| SCHEMBL17086646 | 0.81 | MAPK14 (0.53) | NR3C2MAPK14NT5EKDM5AKDM4C | |
| SCHEMBL15557737 | 0.80 | ALDH1A1 (0.51) | NR3C2MAPK14MAPK9MAPK10MAPK8 | |
| SCHEMBL15556227 | 0.80 | ALDH1A1 (0.51) | NR3C2MAPK14MAPK9MAPK10MAPK8 | |
| SCHEMBL28004022 | 0.80 | MAPK9 (0.54) | NR3C2MAPK14NT5EKDM5AKDM4C | |
| SCHEMBL15556251 | 0.79 | MAPK14 (0.49) | NR3C2MAPK14NT5EKDM5AKDM4C | |
| SCHEMBL28097416 | 0.79 | KDM5A (0.49) | NR3C2MAPK14NT5EKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | claimed |
| CN-104487438-B | Benzisoxazole modulators of neurogenesis | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | disclosed |