Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30165876 | 0.77 | NR1H2 (0.44) | NR1H2NPC1ALDH1A1 | |
| SCHEMBL18199098 | 0.76 | SLC18A3 (0.38) | ALDH1A1MAPT | |
| SCHEMBL255476 | 0.75 | NR1H2 (0.43) | NR1H2MAP4K4NPC1ALDH1A1MAPT | |
| SCHEMBL30912588 | 0.74 | RIPK1 (0.51) | NR1H2NPC1ALDH1A1L3MBTL1 | |
| SCHEMBL17645281 | 0.74 | RIPK1 (0.51) | NR1H2NPC1ALDH1A1L3MBTL1 | |
| SCHEMBL1791760 | 0.74 | RIPK1 (0.51) | NR1H2NPC1ALDH1A1L3MBTL1 | |
| SCHEMBL521801 | 0.73 | NR1H2 (0.49) | NR1H2NPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL1991706 | 0.73 | RIPK1 (0.47) | NR1H2NPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL521802 | 0.72 | NR1H2 (0.47) | NR1H2MAP4K4NPC1ALDH1A1MAPT | |
| SCHEMBL28466498 | 0.72 | NR1H2 (0.57) | NR1H2MAP4K4ALDH1A1MAPTNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106220614-B | Pyridone/pyrazinones, preparation method and application method | 吉利德康涅狄格有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-106220614-A | Pyridone/pyrazinones, its preparation method and using method | 吉利德康涅狄格有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-103189369-B | Pyridone/pyrazinones, methods of making, and methods of use thereof | 吉利德康涅狄格有限公司 | 2016-08-24 | — | — | CN | disclosed |