Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30912588 | 0.83 | RIPK1 (0.51) | NR1H2NPC1UCHL1LMNANPSR1 | |
| SCHEMBL1791760 | 0.83 | RIPK1 (0.51) | NR1H2NPC1UCHL1LMNANPSR1 | |
| SCHEMBL17645281 | 0.83 | RIPK1 (0.51) | NR1H2NPC1UCHL1LMNANPSR1 | |
| SCHEMBL3248455 | 0.80 | KLK7 (0.42) | NR1H2NPC1UCHL1LMNANPSR1 | |
| SCHEMBL1991706 | 0.80 | RIPK1 (0.47) | NR1H2NPC1LMNANPSR1ALDH1A1 | |
| SCHEMBL28379319 | 0.78 | MEN1 (0.43) | NPC1UCHL1LMNANPSR1MEN1 | |
| SCHEMBL28097449 | 0.77 | NR1H2 (0.45) | NR1H2NPC1ALDH1A1 | |
| SCHEMBL8154541 | 0.77 | MEN1 (0.43) | NPC1UCHL1LMNANPSR1MEN1 | |
| SCHEMBL30165827 | 0.77 | NR1H2 (0.43) | NR1H2NPC1UCHL1ALDH1A1RIPK1 | |
| SCHEMBL29679825 | 0.75 | GPR119 (0.47) | NPC1UCHL1LMNANPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |