Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.91 |
| ▸ | MAPT | P10636 | 3/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.91 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.91 |
| ▸ | DRD2 | P14416 | 2/20 | 0.91 |
| ▸ | DRD1 | P21728 | 2/20 | 0.91 |
| ▸ | DRD4 | P21917 | 2/20 | 0.91 |
| ▸ | DRD5 | P21918 | 2/20 | 0.91 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.91 |
| ▸ | DRD3 | P35462 | 2/20 | 0.91 |
| ▸ | RECQL | P46063 | 2/20 | 0.91 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.91 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.91 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.91 |
| ▸ | APEX1 | P27695 | 2/20 | 0.91 |
| ▸ | TP53 | P04637 | 1/20 | 0.91 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.91 |
| ▸ | HTR1A | P08908 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL4329533 | 1.00 | KDM4E (0.91) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL28121550 | 1.00 | KDM4E (0.91) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL28273548 | 0.98 | KDM4E (0.92) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL28131198 | 0.98 | KDM4E (0.88) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL1668345 | 0.98 | KDM4E (0.95) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL28799599 | 0.96 | KDM4E (0.91) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL9166387 | 0.96 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL29362033 | 0.96 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL18159501 | 0.96 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL496657 | 0.96 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109939269-A | The vascular stent material obtained after a kind of vascular stent material surface modification method and its modification and application | 郑州大学 | 2019-06-28 | — | — | CN | claimed |
| CN-109939269-A | The vascular stent material obtained after a kind of vascular stent material surface modification method and its modification and application | 郑州大学 | 2019-06-28 | — | — | CN | disclosed |
| CN-106280242-B | High-intensitive melamine resin fire retardant and preparation method thereof | 郑州峰泰纳米材料有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-106380781-B | Antistatic melamine resin fire retardant and preparation method thereof | 郑州峰泰纳米材料有限公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-107812188-A | Magnetic material with nitric oxide/photo-thermal synergetic antibacterial effect and preparation method and application | 暨南大学 | 2018-03-20 | — | — | CN | disclosed |
| CN-106380781-A | Anti-static melamine resin flame retardant and preparation method thereof | 郑州峰泰纳米材料有限公司 | 2017-02-08 | — | — | CN | disclosed |
| CN-104987866-B | NaREF4@Fe2O3 nucleocapsid nanometer particle and preparation method thereof | 合肥工业大学 | 2017-02-01 | — | — | CN | disclosed |
| CN-106280242-A | High intensity melamine resin fire retardant and preparation method thereof | 郑州峰泰纳米材料有限公司 | 2017-01-04 | — | — | CN | disclosed |