Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.95 |
| ▸ | MAPT | P10636 | 3/20 | 0.95 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.95 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.95 |
| ▸ | DRD2 | P14416 | 2/20 | 0.95 |
| ▸ | DRD1 | P21728 | 2/20 | 0.95 |
| ▸ | DRD4 | P21917 | 2/20 | 0.95 |
| ▸ | DRD5 | P21918 | 2/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.95 |
| ▸ | DRD3 | P35462 | 2/20 | 0.95 |
| ▸ | RECQL | P46063 | 2/20 | 0.95 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.95 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.95 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.95 |
| ▸ | APEX1 | P27695 | 2/20 | 0.95 |
| ▸ | TP53 | P04637 | 1/20 | 0.95 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.95 |
| ▸ | HTR1A | P08908 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL28097643 | 0.98 | KDM4E (0.91) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL28121550 | 0.98 | KDM4E (0.91) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL4329533 | 0.98 | KDM4E (0.91) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL29362033 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL8505 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL16685137 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL9166387 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL18159501 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL496657 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A | |
| Dopamine SCHEMBL29375089 | 0.98 | KDM4E (1.00) | KDM4EMAPTMAPK1TAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118217449-A | Photo-curing injectable polysaccharide-based dopamine hydrogel, and preparation method and application thereof | 中国人民解放军海军军医大学第一附属医院 | 2024-06-21 | — | — | CN | claimed |
| CN-115591026-B | Hydrogel porous silica gel airway stent and preparation method thereof | 山东百多安医疗器械股份有限公司 | 2023-02-17 | — | — | CN | claimed |
| CN-115591026-A | Hydrogel porous silica gel airway stent and preparation method thereof | 山东百多安医疗器械股份有限公司（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-109180970-B | Citric acid crosslinked chitosan and dopamine hydrogel and preparation method thereof | 武汉理工大学 | 2020-08-04 | — | — | CN | claimed |
| CN-118217449-A | Photo-curing injectable polysaccharide-based dopamine hydrogel, and preparation method and application thereof | 中国人民解放军海军军医大学第一附属医院 | 2024-06-21 | — | — | CN | disclosed |
| CN-118217449-A | Photo-curing injectable polysaccharide-based dopamine hydrogel, and preparation method and application thereof | 中国人民解放军海军军医大学第一附属医院 | 2024-06-21 | — | — | CN | disclosed |
| CN-118217449-A | Photo-curing injectable polysaccharide-based dopamine hydrogel, and preparation method and application thereof | 中国人民解放军海军军医大学第一附属医院 | 2024-06-21 | — | — | CN | disclosed |
| WO-2023180536-A1 | IRREVERSIBLE ORGANIC ELECTROCHROMIC MATERIALS | UNIVERSITAET WIEN (AT) | 2023-09-28 | — | — | WO | disclosed |
| CN-115554461-B | Preparation method and application of high-transparency eye adhesive based on gelatin and dopamine | 温州医科大学附属眼视光医院 | 2023-08-04 | — | — | CN | disclosed |
| CN-116496513-A | Antibacterial low-adhesion tough hydrogel and preparation method and application thereof | 苏州大学 | 2023-07-28 | — | — | CN | disclosed |
| CN-115998906-A | In-situ probe gel and preparation method and administration method thereof | 厦门大学附属心血管病医院 | 2023-04-25 | — | — | CN | disclosed |
| CN-115591026-B | Hydrogel porous silica gel airway stent and preparation method thereof | 山东百多安医疗器械股份有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-109180970-B | Citric acid crosslinked chitosan and dopamine hydrogel and preparation method thereof | 武汉理工大学 | 2020-08-04 | — | — | CN | disclosed |
| CN-109180970-B | Citric acid crosslinked chitosan and dopamine hydrogel and preparation method thereof | 武汉理工大学 | 2020-08-04 | — | — | CN | disclosed |
| CN-111072866-A | High-tensile strong-adhesion photo-thermal hydrogel and preparation method and application thereof | 苏州大学 | 2020-04-28 | — | — | CN | disclosed |
| CN-110947027-A | Bacteriostatic self-healing hydrogel dressing for promoting wound repair | 江南大学 | 2020-04-03 | — | — | CN | disclosed |
| CN-107490576-B | A kind of quick detection pesticide, toxin and photonic crystal hydrogel microsphere of nanoparticle and its preparation method and application | 北京化工大学 | 2019-07-05 | — | — | CN | disclosed |
| CN-109180970-A | A kind of citric acid cross-linked chitosan and the hydrogel of dopamine and preparation method thereof | 武汉理工大学 | 2019-01-11 | — | — | CN | disclosed |
| CN-107490576-A | A kind of photonic crystal hydrogel microsphere of quick detection agricultural chemicals, toxin and nano-particle and its preparation method and application | 北京化工大学 | 2017-12-19 | — | — | CN | disclosed |
| WO-2011040969-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OTHER RELATED DISEASES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-04-07 | — | — | WO | disclosed |