Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28115947 | 0.89 | EGLN1 (0.38) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Vinyl Ether SCHEMBL28120747 | 0.78 | CA1 (0.53) | CA1CA4 | |
| Succinic Acid SCHEMBL28488362 | 0.76 | HDAC3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL24440 | 0.76 | HDAC3 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL3012461 | 0.76 | HDAC3 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL9322576 | 0.76 | CA1 (0.32) | CA1BBOX1CA4 | |
| Succinic Acid SCHEMBL27648148 | 0.75 | FFAR3 (0.39) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL351829 | 0.73 | HDAC3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL2923816 | 0.73 | FFAR3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL7569477 | 0.73 | HDAC3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187834-A | α phenylalkyl polyoxyethylenated alcohol disodium succinate salt and preparation method | 南京林业大学 | 2016-12-07 | — | — | CN | disclosed |
| CN-105968338-A | Alpha-phenyl alkyl alcohol polyoxyethylene ether hydroxypropyl allyl ether as well as derivative and preparation method thereof | 南通市晗泰化工有限公司 | 2016-09-28 | — | — | CN | disclosed |