Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.33 |
| ▸ | S100B | P04271 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | FECH | P22830 | 1/20 | 0.32 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15019260 | 0.79 | LMNA (0.34) | FGFR1FGFR3KDM4EALDH1A1PIK3CD | |
| SCHEMBL15023642 | 0.74 | FGFR1 (0.35) | FGFR1FGFR3 | |
| SCHEMBL15023612 | 0.73 | TNIK (0.33) | MAP4K4 | |
| SCHEMBL28098635 | 0.69 | PLK4 (0.32) | PDE5AFGFR1TNK2FGFR3PIK3CA | |
| SCHEMBL279391 | 0.67 | MAP4K4 (0.39) | FGFR1FGFR3ACVRL1MAP4K4KDM4E | |
| SCHEMBL27760000 | 0.66 | FGFR1 (0.49) | FGFR1FGFR3ACVRL1 | |
| SCHEMBL59543 | 0.65 | MAP4K4 (0.41) | MAP4K4 | |
| SCHEMBL25714863 | 0.65 | MAP4K4 (0.41) | TNK2CSNK2A2ACVRL1MAP4K4KDM4E | |
| SCHEMBL22054780 | 0.65 | FGFR1 (0.41) | PDE5AFGFR1TNK2FGFR3ACVRL1 | |
| SCHEMBL15020389 | 0.63 | FGFR1 (0.36) | FGFR1FGFR3RETACVRL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104245700-B | Dibasic benzothienyl-pyrrolo-triazine and the purposes as FGFR inhibitors of kinases thereof | 拜耳制药股份公司 | 2016-11-16 | — | — | CN | disclosed |