Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27993999 | 0.81 | ACVRL1 (0.33) | PLK4AURKADAPK3ROCK2PAK4 | |
| SCHEMBL15020389 | 0.80 | FGFR1 (0.36) | PLK4AURKADAPK3ROCK2PAK4 | |
| SCHEMBL25715512 | 0.70 | FGFR1 (0.34) | FGFR1FGFR3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL28098655 | 0.69 | PDE5A (0.34) | FGFR1FGFR3PIK3CDPIK3CAPIK3CG | |
| SCHEMBL27739607 | 0.68 | FGFR1 (0.47) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL14488117 | 0.67 | PIK3CD (0.35) | PIK3CD | |
| SCHEMBL25714865 | 0.67 | PIK3CD (0.39) | FGFR1FGFR3PIK3CDTNK2CSNK2A2 | |
| SCHEMBL19698008 | 0.67 | PIK3CD (0.31) | PIK3CD | |
| SCHEMBL25715804 | 0.67 | PIK3CD (0.31) | FGFR1FGFR3PIK3CD | |
| SCHEMBL279494 | 0.66 | FGFR1 (0.37) | PLK4AURKADAPK3ROCK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104245700-B | Dibasic benzothienyl-pyrrolo-triazine and the purposes as FGFR inhibitors of kinases thereof | 拜耳制药股份公司 | 2016-11-16 | — | — | CN | disclosed |