SCHEMBL28098945

SCHEMBL28098945

CC[Si](C)(C)NC(=O)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.39
CA2 P00918 2/20 0.39
ALDH1A1 P00352 1/20 0.38
POLB P06746 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
CA3 P07451 2/20 0.33
CA5A P35218 2/20 0.33
CA5B Q9Y2D0 2/20 0.33
CA12 O43570 1/20 0.33
CA4 P22748 1/20 0.33
CA6 P23280 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
FAAH O00519 8/20 0.31
CES1 P23141 5/20 0.30
CES2 O00748 2/20 0.30
CYP1A2 P05177 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28592238 0.83 EPHX1 (0.46) EPHX1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL25308544 0.80 CA2 (0.37) EPHX1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL3647762 0.79 EPHX1 (0.52) EPHX1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL4631292 0.79 EPHX1 (0.41) EPHX1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL22645717 0.77 EPHX1 (0.36) EPHX1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL2354297 0.77 CA2 (0.34) EPHX1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL22613574 0.77 EPHX1 (0.58) EPHX1ALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL248291 0.75 CA2 (0.46) EPHX1CA2ALDH1A1POLBSMN1; SMN2
SCHEMBL28598713 0.75 ALDH1A1 (0.33) EPHX1CA2ALDH1A1POLBSMN1; SMN2
Water SCHEMBL27649766 0.73 CA2 (0.43) EPHX1CA2ALDH1A1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113130990-A Electrolyte and secondary battery using same 深圳市研一新材料有限责任公司 2021-07-16 CN claimed
CN-112858551-B Application and kit of combined metabolic biomarker for diagnosing esophageal squamous carcinoma 中国科学院大连化学物理研究所 2024-07-23 CN disclosed
CN-113130990-A Electrolyte and secondary battery using same 深圳市研一新材料有限责任公司 2021-07-16 CN disclosed
CN-112858551-A Application of combined metabolic biomarker for diagnosing esophageal squamous carcinoma and kit 中国科学院大连化学物理研究所 2021-05-28 CN disclosed
CN-105954389-A Diagnostic kit for bladder cancer and detection method based on human urine glycine, 3-phosphoglyceric acid and cytosine 中国人民解放军第二军医大学 2016-09-21 CN disclosed