Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL7195263 | 0.89 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Ascorbic Acid SCHEMBL28181930 | 0.83 | MAPT (0.52) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Ascorbic Acid SCHEMBL28181929 | 0.83 | MAPT (0.52) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL8746438 | 0.82 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL8669345 | 0.82 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Phthalic Acid SCHEMBL28192884 | 0.80 | TDP1 (0.70) | ALDH1A1KDM4ESMN1; SMN2ACMSDTDP1 | |
| Salicylic Acid SCHEMBL28099781 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL28438472 | 0.79 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Cetostearyl Alcohol SCHEMBL27679072 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Phthalic Acid SCHEMBL28858619 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109789106-A | Sodium bicarbonate in situ conversion to drive transdermal delivery of amine drugs | 考里安国际公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109789134-A | Transdermal delivery system bioequivalent to oral delivery pharmacokinetics | 考里安国际公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109789133-A | Donepezil transdermal delivery system | 考里安国际公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109789113-A | Memantine transdermal delivery system | 考里安国际公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-108135860-A | Transdermal adhesive compositions containing poorly soluble therapeutic agents | 考里安国际公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107405506-A | R-vertebrin agonist mediated hair growth | 小利兰斯坦福大学托管委员会 | 2017-11-28 | — | — | CN | disclosed |
| CN-106456542-A | Aptamers for local delivery | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-105943534-A | Topical LFA-1 antagonists for use in localized treatment of immune related disorders | 萨可德生物科学公司 | 2016-09-21 | — | — | CN | disclosed |