Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.75 |
| ▸ | HPGD | P15428 | 4/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | CA12 | O43570 | 1/20 | 0.75 |
| ▸ | CA1 | P00915 | 1/20 | 0.75 |
| ▸ | CA2 | P00918 | 1/20 | 0.75 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.75 |
| ▸ | CA4 | P22748 | 1/20 | 0.75 |
| ▸ | CA6 | P23280 | 1/20 | 0.75 |
| ▸ | CA7 | P43166 | 1/20 | 0.75 |
| ▸ | CA9 | Q16790 | 1/20 | 0.75 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.75 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL8746438 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL28967262 | 0.89 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Phenyl Propionic Acid SCHEMBL8612428 | 0.89 | KEAP1 (0.68) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL28320595 | 0.89 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Phthalic Acid SCHEMBL4430760 | 0.87 | ALDH1A1 (0.70) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29606432 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1509155 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29360246 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL29362663 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL8433746 | 0.87 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852047-A | Pharmaceutical product comprising a salicylate of an esterifiable ace-inhibitor | CAL INTERNATIONAL LIMITED (IE) | 1998-12-22 | — | — | US | disclosed |
| EP-0750608-A1 | PHARMACEUTICAL PRODUCT COMPRISING A SALICYLATE OF AN ESTERIFIABLE BETA-BLOCKER | CAL INTERNATIONAL LIMITED (IE) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995020571-A1 | A PHARMACEUTICAL PRODUCT COMPRISING A SALICYLATE OF AN ESTERIFIABLE ACE-INHIBITOR | CAL INTERNATIONAL LIMITED (IE) | 1995-08-03 | — | — | WO | disclosed |
| WO-1995020568-A1 | PHARMACEUTICAL PRODUCT COMPRISING A SALICYLATE OF AN ESTERIFIABLE BETA-BLOCKER | CAL INTERNATIONAL LIMITED (IE) | 1995-08-03 | — | — | WO | disclosed |
| EP-0303443-B1 | MULTIVALENT METAL-MODIFIED SALICYLIC ACID RESINS, AND COLOR-DEVELOPING AGENTS AND COPYING PAPER USING THE RESINS | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-12-09 | — | — | EP | disclosed |
| CN-1053212-A | Polyvalent metal modified salicylic acid resin is as the developer of pressure-sensitive carbon paper and the pressure-sensitive carbon paper unit of using this developer | MITSUI TOATSU CHEMICALS (JP) | 1991-07-24 | — | — | CN | disclosed |
| CN-1012681-B | Preparation method of polyvalent metal modified salicylic acid resin | MITSUI TOATSU CHEMICALS (JP) | 1991-05-29 | — | — | CN | disclosed |
| US-4952648-A | Production process of multivalent metal-modified salicylic acid/styrene resin, color-developing agent using the resin and suited for use in pressure-sensitive copying paper sheet and pressure-sensitive copying paper unit employing the agent | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1990-08-28 | — | — | US | disclosed |
| CN-1031235-A | Process for producing polyvalent metal-modified salicylic acid resin, color-developing agent using the resin and suitable for use in pressure-sensitive copying paper, and pressure-sensitive copying paper unit using the color-developing agent | MITSUI TOATSU CHEMICALS (JP) | 1989-02-22 | — | — | CN | disclosed |
| EP-0303443-A2 | Multivalent metal-modified salicylic acid resins, and color-developing agents and copying paper using the resins | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-02-15 | — | — | EP | disclosed |