Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL478481 | 0.97 | TSHR (0.60) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| SCHEMBL30200271 | 0.97 | TSHR (0.60) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL28139825 | 0.97 | TSHR (0.60) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL20598704 | 0.97 | TSHR (0.60) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL25285631 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL28855134 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL28092279 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL28506684 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL15676580 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1FKBP5 | |
| Pyridine SCHEMBL28134601 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1ALDH1A1FKBP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102959660-B | Comprise hydroxamic acid derivs or its salt photoelectric conversion device and preparation method thereof as additive | 巴斯夫欧洲公司 | 2016-09-07 | — | — | CN | disclosed |