SCHEMBL28101787

SCHEMBL28101787

COc1ccc(Oc2ccc(N=C=O)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.48
CYP3A4 P08684 2/20 0.45
TSHR P16473 2/20 0.45
PARP10 Q53GL7 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
NOS3 P29474 2/20 0.42
HTR3E A5X5Y0 1/20 0.42
HTR3B O95264 1/20 0.42
HTR3A P46098 1/20 0.42
HTR3D Q70Z44 1/20 0.42
HTR3C Q8WXA8 1/20 0.42
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
CYP2A6 P11509 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL161063 0.94 CYP3A4 (0.50) CYP3A4TSHRCA12CA1CA2
SCHEMBL50333 0.89 CYP3A4 (0.54) LTA4HCYP3A4TSHRPARP10CA1
SCHEMBL4544188 0.89 CYP3A4 (0.54) LTA4HCYP3A4TSHRPARP10CA1
SCHEMBL4551613 0.89 CYP3A4 (0.54) LTA4HCYP3A4TSHRPARP10CA1
SCHEMBL13246064 0.88 ESR2 (0.47) CYP3A4TSHRCA12CA1CA2
Methylene Chloride SCHEMBL28742344 0.86 CYP3A4 (0.48) CYP3A4TSHRCA12CA1CA2
SCHEMBL668152 0.84 TEAD4 (0.47) CYP3A4TSHRALDH1A1MEN1KMT2A
SCHEMBL1415412 0.83 CYP3A4 (0.48) LTA4HCYP3A4TSHRPARP10ALDH1A1
SCHEMBL4599193 0.83 TRPA1 (0.53) CYP3A4TSHRALDH1A1CYP2A6PTGS2
SCHEMBL242048 0.82 LTA4H (0.50) LTA4HCYP3A4TSHRPARP10CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116768764-A Process for preparing urea derivatives 安道麦阿甘有限公司 2023-09-19 CN claimed
CN-106008276-A Synthesis method of phenylurea herbicide or deuteration-labeled phenylurea herbicide 湖北出入境检验检疫局检验检疫技术中心 2016-10-12 CN claimed
CN-116768764-A Process for preparing urea derivatives 安道麦阿甘有限公司 2023-09-19 CN disclosed
CN-106008276-A Synthesis method of phenylurea herbicide or deuteration-labeled phenylurea herbicide 湖北出入境检验检疫局检验检疫技术中心 2016-10-12 CN disclosed