Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | GAPDH | P04406 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 4/20 | 0.53 |
| ▸ | CCND1 | P24385 | 4/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28102260 | 1.00 | MAPT (0.56) | MAPTTP53KMT2AKDM4EGAPDH | |
| SCHEMBL30639602 | 0.87 | ALOX12 (0.53) | MAPTTP53KMT2AKDM4ECDK4 | |
| SCHEMBL30639623 | 0.85 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1NPSR1MAPK1 | |
| SCHEMBL1528572 | 0.85 | ALDH1A1 (0.60) | MAPTTP53KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL11863184 | 0.84 | ALDH1A1 (0.58) | MAPTTP53KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11875073 | 0.84 | ALDH1A1 (0.58) | MAPTTP53KMT2AKDM4EALDH1A1 | |
| SCHEMBL8020401 | 0.83 | MAPT (0.67) | MAPTTP53KMT2AKDM4EGAPDH | |
| SCHEMBL8887137 | 0.80 | CDK4 (0.52) | MAPTTP53KMT2AKDM4EGAPDH | |
| SCHEMBL30639604 | 0.80 | HPGD (0.50) | MAPTKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL30639596 | 0.80 | ALDH1A1 (0.50) | MAPTTP53KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117045647-A | Application of 4-hydroxypyrazole compounds, derivatives and salts thereof in preparation of iron death inhibiting drugs | 浙江大学 | 2023-11-14 | — | — | CN | claimed |
| CN-104356066-B | Preparation method of multi-substituted 4-hydroxypyrazole derivative | 浙江大学 | 2017-01-18 | — | — | CN | claimed |
| CN-117045647-A | Application of 4-hydroxypyrazole compounds, derivatives and salts thereof in preparation of iron death inhibiting drugs | 浙江大学 | 2023-11-14 | — | — | CN | disclosed |
| CN-104356066-B | Preparation method of multi-substituted 4-hydroxypyrazole derivative | 浙江大学 | 2017-01-18 | — | — | CN | disclosed |